Chrysler Building

located on the eastern side of Lexington Avenue between 42nd and 43rd streets. The land was donated to The Cooper Union for the Advancement of Science and Art in 1902. The site is roughly a trapezoid with a 201-foot-long (61 m) frontage on Lexington Avenue; a 167-foot-long (51 m) frontage on 42nd Street; and a 205-foot-long (62 m) frontage on 43rd Street. The site bordered the old Boston Post Road, which predated, and ran aslant of, the Manhattan street grid established by the Commissioners' Plan of 1811. As a result, the east side of the building's base is similarly aslant.

The Grand Hyatt New York hotel and the Graybar Building are located across Lexington Avenue, while the Socony–Mobil Building is located across 42nd Street. In addition, the Chanin Building is located to the southwest, diagonally across Lexington Avenue and 42nd Street.